About Virtlab

 Virtlab Demonstration

All exercises in Dynamic Models in Biochemistry have been completed and will be ported to Virtlab at a later date.

Dynamic Models in Biochemistry

Daniel E. Atkinson, University of California, Los Angeles 
Steven G. Clarke, University of California, Los Angeles
Douglas C. Rees, California Institute of Technology

The quantitative aspects of biochemistry are often intimidating to beginning and even some advanced students. Dynamic Models in Biochemistry takes your students from an exploration of simple equilibrium relationships (including acid-base relationships) and enzyme activities to a consideration of the behavior of polymers and metabolic pathways -- all in a dynamic environment where the student can interrogate each physical process with both prompted and independently motivated "what-if" questions.

Students learn how to
  • Build models of simple equilibrium and acid-base behavior (including polyprotic acids).
  • Build models of simple Michaelis enzymes as well as enzymes exhibiting cooperative behavior of varying degrees of complexity.
  • Explore the dynamics of metabolism through models of sequential reactions, branch points, feedback control, etc.
  • Build models of passive, facilitated, and active transport across membranes and explore the differing consequences of these transport modes.
  • Explore the restrictions on torsion angles that steric hindrance brings to bear on large molecules and to examine many of the forces that influence macromolecular structure.
Table of Contents
  • CHAPTER 1: Getting Started 
  • CHAPTER 2: Tips on Using Electronic Spreadsheets
  • CHAPTER 3: Equilibrium and Acid-Base Relationships
  • CHAPTER 4: Enzyme Kinetics
  • CHAPTER 5: Metabolism
  • CHAPTER 6: Membrane Transport
  • CHAPTER 7: Structure and Stability of Macromolecules